Doctors have emphasized the importance of maintaining a healthy weight to improve overall health, and a large study also found that the risk of future gastrointestinal cancer can also be reduced.
The researchers found that an obese or overweight BMI in early and middle adulthood was associated with an increased risk of gastrointestinal cancer. It also found that regular aspirin use did not reverse this increased risk in obese and overweight people.
Colorectal cancer is the 3rd most common cancer among women and men in the United States. Although improvements in screening have led to the detection of many early-stage cancers, more than 150,000 new cases of rectal and colon cancer are diagnosed each year.
With obesity rates increasing worldwide and 70% of the American population considered obese or overweight, understanding the relationship between obesity and risk of long-term diseases, including cancer, is critical to improving public health.
This study suggests that obesity or being overweight at certain stages of life may increase a person’s risk of gastrointestinal cancer in the near future.
The researchers wanted to understand how changes in BMI that occur at several stages of adulthood may affect the risk of gastrointestinal cancer.
Previously collected data were evaluated from 131,161 individuals enrolled in a randomized trial examining the effectiveness of screening for ovarian, colorectal, lung, and prostate cancer in reducing cancer-related mortality. The study was conducted between 1993 and 2001 among people aged 55 to 74 when they were enrolled.
Obesity is the result of accumulation and accumulation of white adipose tissue. An inflammatory response can be triggered and immune cell dysfunction can be triggered by adipocytes, leading to the development of disease that includes cardiovascular diseases such as stroke, metabolic conditions such as type 2 diabetes, and certain cancers that are affected by adipocytes. :
For this analysis, age 20 was considered early adulthood, age 50 as middle adulthood, and age 55 or older as later adulthood.
BMI was determined from height and weight questionnaires completed by participants at baseline for these age units.
They were then classified based on the WHO criteria for underweight, which is BMI less than 18.5, normal BMI 18.5 to 24.9, overweight 25 to 29.9, and obese. which is a BMI above 30.
They were also asked to report how often they took aspirin or aspirin-containing products during the study. Then they were followed for 13 years.
An increased risk of gastrointestinal cancer has been observed in obese and overweight people in early, middle and later adulthood. Increasing BMI over time is also associated with an increased risk of gastrointestinal and non-colorectal cancers. This relationship was not altered by regular aspirin use.
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